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Tumor Resistance

Tumor resistance is one of the biggest problems in cancer therapy, in which cancer cells resist or survive treatments, resulting in disease relapse or progression. The seminar "Tumor Resistance" discusses understanding the mechanisms of resistance and overcoming resistance.".

Cancer cells may acquire resistance through a variety of mechanisms, such as genetic mutation, epigenetic modification, alternative signaling pathway activation, and adaptation to the tumor microenvironment. Drug efflux pumps, DNA repair, and immune evasion also play a role in therapeutic resistance. Knowledge of these mechanisms is important in developing more efficient treatment regimens.

This session discusses strategies to overcome resistance, including combination regimens, adaptive treatment schedules, and new targeted therapies. Personalized medicine, based on genomic and molecular profiling, enables the identification of resistant tumor cells and adaptation of therapy accordingly. Furthermore, continued research in biomarkers of resistance facilitates early detection and treatment.

Participants will learn about the biological mechanisms of tumor resistance, current approaches to overcoming it, and promising therapies in development. This session highlights the significance of the understanding of resistance mechanisms for achieving better treatment outcomes, improved patient care, and the advancement of new, long-lasting cancer treatments.

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