Oncone genes are genes that, when mutated or overexpressed, lead to cancer growth through promotion of uncontrolled cell growth and survival. The subject "Oncogenes" is devoted to the study of their biological function, clinical significance, and targeting for treatment in oncology.".
Eukaryotic cell genes referred to as proto-oncogenes regulate cell differentiation and proliferation. Upon mutation, amplification, or translocation, proto-oncogenes become oncogenes, which contribute to the initiation of tumors, metastasis, and growth. Oncogenes are essential to the signaling pathways that stimulate proliferation, apoptosis, and angiogenesis and are hence essential drivers of cancer biology.
The session addresses techniques to therapeutically target oncogenes specifically, including small molecule inhibitors, monoclonal antibodies, and RNA treatments. Identification of the specific oncogenic drivers of a particular tumor allows for precision medicine strategies, delivering targeted therapies to achieve benefit and minimize toxicity. Biomarker-based detection and molecular characterization are required to identify actionable oncogenes and assess treatment response.
Attendees will gain insights into mechanisms, clinical significance, and new research on oncogenes. This session emphasizes the value of targeting oncogenes to design customized cancer therapies, improve patient outcomes, and advance the boundary of precision oncology