The cancer microenvironment refers to the intricate ensemble of cells, molecules, and structures surrounding cancer cells and is pivotal to cancer growth, metastasis, and response to therapy. The session "Cancer Microenvironment" emphasizes comprehension of these interactions and their implications on precision oncology.".
Components of the microenvironment are immune cells, fibroblasts, endothelial cells, extracellular matrix, and signaling molecules. These components determine tumor growth, angiogenesis, immune evasion, and therapy resistance. Dysregulation of the microenvironment may encourage metastasis and lower the efficacy of therapies such as chemotherapy, immunotherapy, and targeted therapies.
The session examines methods to manipulate the tumor microenvironment to improve treatment outcomes. Strategies involve targeting immunosuppressive cells, altering extracellular matrix components, normalizing tumor vasculature, and synergizing therapies for overcoming resistance. New technologies like single-cell sequencing, spatial transcriptomics, and imaging tools give precise insights into microenvironmental processes.
Participants will learn about the biology, clinical significance, and therapeutic potential of the cancer microenvironment. This session highlights how knowledge and targeting of the tumor microenvironment can enhance the effectiveness of treatment, counteract resistance, and promote personalized cancer therapies, ultimately improving patient outcomes and advancing precision oncology.